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2020年

• Scalable Total Syntheses and Structure‐Activity Relationships of Haouamine A, B, and their Derivatives as Stable Formate Salts.

       Tsukamoto H, Nakamura S, Tomida A, Doi T, Chem. Eur. J., 2020, 26(55), 12528–12532.

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• Unique responses of Helicobacter pylori to exogenous hydrophobic compounds.

        Shimomura H, Wanibuchi K, Hosoda K, Amgalanbaatar A, Masui H, Takahashi T, Hirai Y, Chemistry and Physics of Lipids,

　　　2020, 229, 104908.

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• Photoredox Michael addition of phenylmalononitrile onto α, β-unsaturated carboxylic acid.

        Hirahama T, Umezawa M, Shoji M, Tet. Lett., 2020, 61(18), 151824.

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• Antibacterial effect of indene on Helicobacter pylori correlates with specific interaction between its compound and dimyristoyl-phosphatidylethanolamine.

        Wanibuchi K, Takezawa M, Hosoda K, Amgalanbaatar A, Tajiri K, Koizumi Y, Niitsu S, Masui H, Sakai Y, Shoji M,

        Takahashi T, Hirai Y, Shimomura H, Chemistry and Physics of Lipids, 2020, 227, 104871.

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• [4 + 3]付加環化を鍵反応とするエングレリンAの全合成”.

        萩原秀一, 花屋賢悟, 須貝　威, 庄司　満, 化学工業、2020, 11(2), 79–82.

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2019年

• Palladium(0)-Catalyzed [4+2] Annulation of Salicylaldehydes and Propargyl Carbonates to Produce 3,4-Dihydro-2-Methylene-2H-1-Benzopyran-4-Ols.

        Kawase A, Omura H, Doi T, Tsukamoto H, Chem. Lett., 2019, 48(11), 1402–1405.

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• Palladium(0)-Lithium Iodide-Cocatalyzed Asymmetric Hydroalkylation of Conjugated Enynes with Pronucleophiles Leading to 1,3-Disubstituted Allenes.

        Tsukamoto H, Konno T, Ito K, Doi T, Org. Lett., 2019, 21(17), 6811–6814.

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• Key Factors for High Diastereo- and Enantioselectivity of Umpolung Cyclizations of Aldehyde-Containing Allylpalladium Intermediates.

        Tsukamoto H, Kawase A, Omura H, Doi T, Bull. Chem. Soc. Jpn., 2019, 92(10), 1743–1753.

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• Palladium-Catalyzed Umpolung Type-II Cyclization of Allylic Carbonate-Aldehydes Leading to 3-Methylenecycloalkanol Derivatives.

        Tsukamoto H, Kawase A, Doi T,  Adv. Synth. Catal., 2019, 361(16), 3733–3738.

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• Donor–acceptor polymers containing thiazole-fused benzothiadiazole acceptor units for organic solar cells.

        Nakamura T, Ishikura Y, Arakawa N, Hori M, Satou M, Endo M, Masui H, Fuse S, Takahashi T, Murata Y, Murdey R,

        Wakamiya A, RSC Adv., 2019, 9, 7107–7114.

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• Determination of human γ,δ-T cell-mediated cytotoxicity using a non-radioactive assay system.

        Tagod M S O, Mizuta S, Sakai Y, Iwasaki M, Shiraishi K, Senju H, Mukae H, Morita C T, Tanaka Y, J. Immunol.

        Methods., 2019, 466, 32-40.

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• Development of a Novel Antibacterial Medicine that Targets a Characteristic Lipid of the Cell Membranes of Helicobacter pylori.

        Wanibuchi K, Masui H, Takahashi T, Shimomura H, IntechOpen Gastritis - New Approaches and Treatments, 2019

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2018年

• Selective Monoprotection of Symmetrical Diols in a Flow Reactor.

        Masui H, Takizawa M, Sakai Y, Kajiwara Y, Wanibuchi K, Shoji M, Takahashi T, International J. Org. Chem., 2018, 8,

        264–271.

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• Safe Hydroformylation of Aliphatic Alkene in a Flow Reactor.

        Masui H, Honda E, Niitsu S, Shoji M, Takahashi T, International J. Org. Chem., 2018, 8, 135–141.

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• Indene Compounds Synthetically Derived from Vitamin D Have Selective Antibacterial Action on Helicobacter pylori.

        Wanibuchi K, Hosoda K, Ihara M, Tajiri K, Sakai Y, Masui H, Takahashi T, Hirai Y, Shimomura H, Lipids, 2018, 53, 393–401.

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• Identification and Characterization of a Novel NADPH Oxidase 1 (Nox1) Inhibitor That Suppresses Proliferation of Colon and Stomach Cancer Cells.

        Yamamoto T, Nakano H, Shiomi K, Wanibuchi K, Masui H, Takahashi T,  Urano Y, Kamata T,  Bio. Pharm. Bull., 2018, 41,

        419–426.

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• D–π–A Dyes Containing Novel Hydantoin Anchoring Groups for Dye-sensitized Solar Cells.

        Masui H, Maitani M, Fuse S, Yamamura A, Ogomi Y, Hayase S, Kaiho T, Tanaka H, Wada Y, Takahashi T, Asian J. Org.

        Chem., 2018, 7, 458–464.

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• Synthesis of enantiomerically enriched drug precursors and an insect pheromone via reduction of ketones using commercially available carbonyl reductase screening kit “Chiralscreen® OH”.

        Nagai T, Sakurai S, Natori N, Hataoka M, Kinoshita T, Inoue H, Hanaya K, Shoji M, Sugai T, Bioorganic & Medicinal

        Chemistry, 2018, 26(7), 1304-1313.

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• 13C-phenylalanine breath test and serum biopterin in schizophrenia, bipolar disorder and major depressive disorder.

        Teraishi T, Kajiwara M, Hori H, Sasayama D, Hidese S, Matsuo J, Ishida I, Kajiwara Y, Ozeki Y, Ota M, Hattori K, Higuchi T,

        Kunugi H, J. Psychiatr. Res, 2018, 99 142-150.

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• Formal synthesis of englerin A utilizing regio- and diastereoselective [4+3] cycloaddition.

        Hagihara S,Hanaya K, Sugai T, Shoji M, The Journal of Antibiotics, 2018, 71, 257–262.

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• Chemoenzymatic approaches to the synthesis of the (1S,2R)-isomer of benzyl 2-hydroxycyclohexanecarboxylate.

       Tsunekawa R, Hanaya K, Higashibayashi S, Shoji M, Sugai T,  Molecular Catalysis, 2018, 444, 84-89.

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• Synthesis of 3β-tert-Butyldimethylsiloxy-22-phenylthio-23,24-bisnorchola-5,9(11)-diene and Reductive Nucleophilic Attack on a Branched Aliphatic Aldehyde.

       Nagai T, Hanaya K, Higashibayashi S, Shoji M, Sugai T,  Chemical and Pharmaceutical Bulletin, 2018, 66(3), 334-338.

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2017年

• Chemo-enzymatic Synthesis of (R)-5-Hydroxymethyl-2-isopropyl-5-methylcyclopent-1-en-1-yl Trifluoromethylsulfonate, a Potential Chiral Building Block for Multicyclic Terpenoids.

        Kuwata K, Hanaya K, Sugai T, Shoji M, Tetrahedron: Asymmetry., 2017, 28(7), 964-968.

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• Synthesis of trans,trans,cis-Fused Tetracyclic Skeleton via Radical Domino Cyclization.

        Furuta M, Hanaya K, Sugai T, Shoji M, Tetrahedron., 2017, 73(16), 2316–2322.

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• One-Pot, Diversity-Oriented Synthesis of Aryl-Substituted Benzoxacycles Including Benzofuran, Coumarin, and Benzoxazepine.

        Masui H, Ohkawa E, Kitahara R, Wanibuchi K, Kaiho T, Takahashi T, Heterocycles., 2017, 14(12), 2273-2290.

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• Synthesis of End-functionalized Glycopolymers Containing α(2,8) Disialic Acids by π-Allyl Nickel Catalyzed Coordinating Polymerization and Their Interaction with Siglec-7.

        Ohira S, Yasuda Y, Tomita I, Kitajima K, Takahashi T, Sato C, Tanaka H,  Chem. Commun., 2017, 53, 553-556.

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• Oligomer formation of a tea polyphenol, EGCG on its sensing molecule the 67-kDa laminin receptor.

        Huang Y, Sumida M, Kumazoe M, Sugihara K, Suemasu Y, Yamada S, Yamashita S, Miyakawa J, Takahashi T, Tanaka H,

        Fujimura Y, Tachibana H, Chem. Commun., 2017, 53, 1941-1944.

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• Chemical synthesis and evaluation of a disialic acid-containing dextran polymer as an inhibitor of sialic acid binding immunoglobulin-like lectin, Siglec 7.

        Yamaguchi S, Yoshimura A, Yasuda Y, Mori A, Tanaka H, Takahashi T, Kitajima K, Sato C, ChemBioChem., 2017, 18,

        1194-1203.

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• PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma.

        Kumazoe M, Takai M, Hiroi S, Takeuchi C, Yamanouchi M, Nojiri T, Onda H, Bae J, Huang Y, Takamatsu K, Yamashita S,

        Yamada S, Kangawa K, Takahashi T, Tanaka H, Tachibana H, Sci. Rep., 2017, 7, 1917.

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• Crystal structure of octocoral lectin SLL-2 complexed with Forssman antigen tetrasaccharide.

        Kita A, Jimbo M, Sakai R, Morimoto Y, Takeuchi R, Tanaka H, Takahashi T, Miki K, Glycobiology, 2017, 27, 696-700.

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• Solution-phase automated synthesis of α-amino aldehyde as a versatile intermediate.

       Masui H, Yosugi S, Fuse S, Takahashi T,  Beilstein J. Org. Chem., 2017, 13, 106-110.

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2016年

• Synthesis and Evaluation of Thiophene-based Organic Dyes Containing a Rigid and Non-Planar Donor with Secondary Electron Donors for Use in Dye-Sensitized Solar Cells.

        Fuse S, Takahashi R, Maitani M, Wada Y, Kaiho T, Tanaka T, Takahashi T, Eur. J. Org. Chem., 2016, 21, 508-517.

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• Rapid Synthesis of D-A'-π-A Dyes through a One-Pot Three-Component Suzuki–Miyaura Coupling and an Evaluation of their Photovoltaic Properties for Use in Dye-Sensitized Solar.

        Irie S, Fuse S, Maitani M, Wada Y, Ogomi Y, Hayase S, Kaiho T, Masui H, Tanaka H, Takahashi T,  Chem. Eur. J., 2016, 22, 　　　2507–2514.

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• Synthesis of [123I]-Iodometomidate from a Polymer-Supported Precursor with a Large Excluded Volume.

        Nakagawa C, Toyama M, Takeuchi R, Takahashi T, Tanaka H, RSC Adv., 2016, 6, 12215-12218.

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• The Design, Synthesis, and Evaluation of 1,5,7-Trisubstituted-3-pyridyl-xanthones for Use as Insecticides Starting from Pyripyropene A.

        Fuse S, Matsumura K, Johmoto K, Uekusa H, Tanaka H, Hirose T, Sunazuka T, Ōmura S, Takahashi T, Chem. Eur. J., 2016, 　　　22, 18450–18455.

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2015年

• Solid-supported reagents composed of a copolymer possessing 2-O-sulfonyl mannosides and phase-transfer catalysts for the synthesis of 2-fluoroglucose.

        Takeuchi R, Sakai Y, Tanaka H, Takahashi T, Bioorg. Med. Chem. Lett., 2015, (23), 5500–5503.

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• Sequential SNAr Reaction/Suzuki–Miyaura Coupling/C−H Direct Arylations Approach for the Rapid Synthesis of Tetraaryl-Substituted Pyrazoles,

　　　Morita T, Kobayashi D, Matsumura K, Johmoto K, Uekusa H, Fuse S, Takahashi T, Chem. Asian J., 2015, (10), 1626–1630.

 

• PE859, a Novel Tau Aggregation Inhibitor, Reduces Aggregated Tau and Prevents Onset and Progression of Neural Dysfunction In Vivo,

         Okuda M, Hijikuro I, Fujita Y, Wu X, Nakayama S, Sakata Y, Noguchi Y, Ogo M, Akasofu S, Ito Y, Soeda Y, Tsuchiya N,

         Tanaka N, Takahashi T, Sugimoto H, PLoS ONE, 2015, 10(2).

 

• Asymmetric Total Synthesis of ent-Pyripyropene A,

　　　Fuse S, Ikebe A, Oosumi K, Karasawa T, Matsumura K, Izumikawa M, Johmoto K, Uekusa H, Shin-ya K, Doi T,

　　　Takahashi T,Chem. Eur. J., 2015, 21, 9454–9460.

 

• Rapid Synthesis of Thiophene-Based, Organic Dyes for Dye-Sensitized Solar Cells (DSSCs) by a One-Pot, Four-Component Coupling Approach,

　　　Matsumura K, Yoshizaki S, Maitani M, Wada Y, Ogomi Y, Tanaka H, Takahashi T, Chem. Eur. J., 2015, 21, 9742–9747.

 

• Regioselective, One-Pot, Three-Component Synthesis of 1,3,4- and 1,3,5-Triarylpyrazoles from 1- and 2-Aryl-1-alkenyl Sulfones,

　　　Fuse S, Sugiyama H, Kobayashi D, Iijima Y, Matsumura K, Tanaka H, Takahashi T, Eur. J. Org. Chem., 2015,

　　　4756–4764.

 

• Reagent Control of a Birch Reduction for the Synthesis of a 2-Deoxyoligosaccharide Possessing a 1,4-Dialkylhydroquinone,

　　　Yamaguchi S, Tanaka H, Takahashi T, Eur. J. Org. Chem., 2015, 4939–4943.

 

• Facile, One-Step Synthesis of 5-Substituted Thieno[3,4-c]pyrrole-4,6-dione by Palladium-Catalyzed Carbonylative Amidation,

　　　Fuse S, Takahashi R, Takahashi T, Eur. J. Org. Chem., 2015, 3430–3434.

 

• The chemoselective O-glycosylation of alcohols in the presence of a phosphate diester and its application to the synthesis of oligomannosylated phosphatidyl inositols,

　　　Ohiraa S, Yamaguchi Y, Takahashi T, Tanaka H, Tetrahedron, 2015, 71, 6602–6611.

 

• Palladium-catalyzed double carbonylation-based diversity-oriented synthesis of 3,4-dihydroisoquinoline-1-carboxamides,

　　　Masui H, Ishizawa N, Fuse S, Takahashi T, Tetrahedron, 2015, 71, 6354–6360.

 

• Identification and characterization of a vitamin D3 decomposition product bactericidal against Helicobacter pylori

　　　K Hosoda, H Shimomura, K Wanibuchi, H Masui, A Amgalanbaatar,

　　　S Hayashi, T Takahashi, Y Hirai, Scientific Reports, 2015, (5), 8860.

 

2014年

• Total Synthesis of (+)-Antimycin A3b on Solid Supports

Yusuke Iijima, Osamu Kimata, Santida Decharin, Hisashi Masui, Yoichiro Hirose and Takashi Takahashi

Eur. J. Org. Chem., 2014, (22), 4725-4730.

 

• Synthesis of EDOT-containing organic dyes via one-pot, four-component Suzuki-Miyaura coupling procedure and their evaluation of photovoltaic properties

Shinichiro Fuse, Yuya Asai, Sakae Sugiyama, Keisuke Matsumura, Masato M. Maitani, Yuji Wada, Yuhei Ogomi, Shuzi Hayase, Tatsuo Kaiho and Takashi Takahashi, Tetrahedron, 2014, 70, (45), 8690-8695.

 

 

• Rapid library synthesis of amphiphiles based on a dioxinone scaffold and identification of nonlamellar liquid crystals

Shinichiro Fuse, Kentarou Nakamura, Yuto Mifune, Hironori Marubayashi, Ichiro Hijikuro, Shuichi Nojima, Hiroshi Tanaka and Takashi Takahashi, Synlett, 2014, 25, (19), 2806-2813.

 

• Elucidation of the structure-property relationship of p-type organic semiconductors through rapid library construction via a one-pot, Suzuki-Miyaura coupling reaction

Shinichiro Fuse, Keisuke Matsumura, Atsushi Wakamiya, Hisashi Masui, Hiroshi Tanaka, Susumu Yoshikawa, and Takashi Takahashi, ACS Comb. Sci., 2014, 16, (9), 494-499.
Selected as most read articles 8-9/2014 in ACS Comb. Sci.

 

• Total synthesis and stereochemistry revision of mannopeptimy-cin aglycone

Shinichiro Fuse, Hirotsugu Koinuma, Atsushi Kimbara, Miho Izumikawa, Yuto Mifune, Haiyin He, Kazuo Shin-ya, Takashi Takahashi, and Takayuki Doi, J. Am. Chem. Soc., 2014, 136, (34), 12011-12017.

 

• Development of dual targeting inhibitors against aggregations of amyloid-β and tau protein

Shinichiro Fuse, Keisuke Matsumura, Yuki Fujita, Hachiro Sugimoto, and Takashi Takahashi

Eur. J. Med. Chem., 2014, 85, 228-234.

 

• Rapid and structurally diverse synthesis of multi-substituted β-keto amide derivatives based on a dioxinone scaffold

Shinichiro Fuse, Hayato Yoshida, Kazuya Oosumi and Takashi Takahashi, Eur. J. Org. Chem., 2014, (22), 4854-4860.

 

• Micro-flow technology: another solution for the site-selective modification of multi-functionalized molecules

Shinichiro Fuse, Yuto Mifune, Nobutake Tanabe, Takashi Takahashi, Synlett (Synpacts, invited), 2014, 25, (15), 2087-2092.
Highlighted in ChemInform, 2014, 45, (49).

 

• Elucidating the structure-property relationship of donor-pi-acceptor dyes for DSSCs through rapid library synthesis via a one-pot procedure

Shinichiro Fuse, Sakae Sugiyama, Masato M. Maitani, Yuji Wada, Yuhei Ogomi, Shuzi Hayase, Ryuzi Katoh, Tatsuo Kaiho, and Takashi Takahashi, Chem. Eur. J., 2014, 20, (34), 10685-10694 (Special Issue Young Chemist, invited).

 

• Synthesis of a phosphatidylinositol dimannoside using 2-(azidomethyl)benzoate mannosyl donors

Shuichi Ohira, Yoshiki Yamaguchi, Takashi Takahashi, and Hiroshi Tanaka, Heterocylcs, 2014, 89, 763-774

 

• Synthesis of a Dextran-Based Bone Tracer for in vivo Magnetic Resonance and Optical Imagings by Two Orthogonal Coupling Reactions

Hiroshi Tanaka, Sho Yamaguchi, Jun-ichiro Jo, Ichio Aoki, Yasuhiko Tabata and Takashi Takahashi
RSC Adv., 2014, 4, 7561-7565

 

• NMR study of short β1,3-glucans provides insights into the structure and interaction with Dectin-1

Shinya Hanashima, Akemi Ikeda, Hiroshi Tanaka, Yoshiyuki Adachi, Naohito Ono, Takashi Takahashi, Yoshiki Yamaguchi*
Glycoonj. J., 2014, 31, 199-207

 

• An efficient amide bond formation through the rapid and strong activation of carboxylic acids in a micro-flow reactor

Shinichiro Fuse, Yuto Mifune, and Takashi Takahashi, Angew. Chem. Int. Ed., 2014, 53, 851-855